Elevated levels of inhibitory neurosteroids, namely allopregnanolone, can produce paradoxical effects, such as negative mood, anxiety, irritability, and aggression.
en.wikipedia.org Adverse central nervous system effects include headache, migraine, dizziness, mental depression, chorea, nervousness/anxiety, mood disturbances, irritability, and worsening of epilepsy.
en.wikipedia.org Altered testosterone/oestradiol ratios can cause problems with memory function, depression, irritability, sleep, fatigue and occasionally even hot flushes.
theconversation.com Subcutaneous injections of calcitonin in patients suffering from mania resulted in significant decreases in irritability, euphoria and hyperactivity and hence calcitonin holds promise for treating bipolar disorder.
en.wikipedia.org Clues to a person's vulnerability to migraine include a tendency to frequent yawning, travel sickness, a hangover after just one drink and, for women, increased irritability before periods.
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