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The second stage - the internalization of bound toxin into the cytosol by endocytosis.
After internalization light chain acts as a Zn2 + -dependent protease cytosol selectively splitting the SNAP-25 that the third stage leads to the blockade of acetylcholine release from presynaptic terminals of cholinergic neurons.
The net effect of this process is resistant hemodenervatsiya.
pharma-base.ruDie zweite Stufe - die Internalisierung der gebundenen Toxins in das Cytosol durch Endocytose.
Nach der Internalisierung leichte Kette fungiert als Zn2 + -abhangige Protease Cytosol selektiv Spaltung der SNAP-25, dass die dritte Etappe fuhrt die Blockade der Acetylcholin-Freisetzung aus prasynaptischen Nervenendigungen cholinergen Neuronen.
Der Netto-Effekt dieses Prozesses ist resistent hemodenervatsiya.
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- ligature
- ligger
- light
- light bulb
- light buoy
- light chain light chain lc
- light commercial vehicle
- light compensation point
- light cream
- light dependence
- light-dependent reaction